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Georgia Journal of Science

Article Title

DETERMINATION OF THE BINDING SITE OF ADENOVIRUS E4 11K ON THE CELLULAR PROTEIN DDX6

Abstract

Adenovirus is a double stranded DNA virus responsible for localized infections, such as upper respiratory tract infections. The virus takes over the cell by taking control of host cell replication mechanisms as well as controlling host cell protein synthesis machinery. One of the functions of adenovirus E4 11k protein is in turning off host cell protein synthesis and regulating late viral gene expression. E4 11k is known to disrupt cellular RNA processing bodies (P-bodies) through an interaction with a P-body protein, Ddx6. Our research goal is the identification of the binding site of Ddx6 on the E4 11k protein. Once this site is narrowed down to a single amino acid or sequence of amino acids, we aim to ascertain if the binding of E4 11k with Ddx6 and subsequent disruption of P-bodies during an adenovirus infection is involved in the control of host cell and late viral protein synthesis.

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