In this experiment polyalanine was folded into globular, sheeted, and helical structures through the use of carbon nanotubes. The rigidity of the nanotubes allowed for molding the polyalanine into the various structures. Nanotubes of different diameters and volumes were used in this experiment. Once the three dimensional peptide structures were formed and detached from the carbon nanotubes, a number of thermodynamic calculations were performed. Computational methods were used to calculate parameters such as Gibbs free energy, enthalpy, entropy, and molecular volume. By attaining the measurements of the phi and psi angles, Ramachandran plots were constructed using linear, globular, sheeted, and helical protein structures.
Allen, Caley; Bailey, Travis; Bowen, Opie; Bryant, Virginia; Kitchens, Nickolas; Lackey, Jason; Mills, Inez; Patel, Om; Richardson, Nicholas; Sermons, Shanda; Shaw, Thomas; Stafford, Calandra; Stoney, Tiffany; Ward, Chad; Zipperer, Samuel; and Manning, Thomas J.
"Constructing Globular, Sheeted, and Helical Polyalanine Structures using Nanotubes as Templates for Computational Studies,"
Georgia Journal of Science, Vol. 64, No. 2, Article 8.
Available at: https://digitalcommons.gaacademy.org/gjs/vol64/iss2/8