Synthesis and anti-proliferative activity of N,N’-bis-substituted -2,4-triazolium salts with various substituents

Authors

ZiJie Lin, Department of Chemistry, Columbus State University, 4225 University Ave, Columbus, GA 31907-5645, USAFollow
Camila Cardenas, Department of Chemistry, Columbus State University, 4225 University Ave, Columbus, GA 31907-5645, USAFollow
Jared Bies, Department of Chemistry, Columbus State University, 4225 University Ave, Columbus, GA 31907-5645, USAFollow
Jacqueline Strickland, Department of Chemistry, Columbus State University, 4225 University Ave, Columbus, GA 31907-5645, USAFollow
John D. Gorden, Department of Chemistry, Auburn University, Auburn, AL 36849 , USAFollow
Monica Frazier, Department of Biology, Columbus State University, 4225 University Ave, Columbus, GA 31907-5645, USAFollow
Jonathan M. Meyers, Department of Chemistry, Columbus State University, 4225 University Ave, Columbus, GA 31907-5645, USAFollow
Kerri L. Shelton, Department of Chemistry, Columbus State University, 4225 University Ave, Columbus, GA 31907-5645, USAFollow

Abstract

The need for a more desirable anti-tumor agent with fewer side effect is urgent to solve the issue of cancer which is currently one of the leading causes of death in the United States. Recently, imidazolium and benzimidazolium salts have been discovered to possess comparable anti-proliferative activity to cisplatin, a FDA approved drug. Triazolium salts, closely related to the imidazolium and benzimidazolium salts, has yet to be discovered to exhibit any anti-proliferative activity yet. A series of N,N’-bis-substituted triazolium salts are synthesized, characterized, and tested for solubility and anti-proliferative activity against a panel of breast and prostate cancer cell lines.

Acknowledgements

Funded by a Student Research and Creative Endeavors Grant from Columbus State University and CSU Department of Chemistry. Thank you also to Spelman College.

Recommended Citation

Lin, ZiJie; Cardenas, Camila; Bies, Jared; Strickland, Jacqueline; Gorden, John D.; Frazier, Monica; Meyers, Jonathan M.; and Shelton, Kerri L. (2018) "Synthesis and anti-proliferative activity of N,N’-bis-substituted -2,4-triazolium salts with various substituents," Georgia Journal of Science, Vol. 76, No. 1, Article 121.
Available at: https://digitalcommons.gaacademy.org/gjs/vol76/iss1/121