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Georgia Journal of Science

Article Title

SELECT AGONISTS OF THE ARYL HYDROCARBON RECEPTOR AND THEIR EFFECTS ON LACTIC ACID LEVELS IN HUMAN HEPATOCYTES**

Abstract

Diabetes is disease of dysregulated glucose transport and metabolism. This disease state can also result in elevated lactic acid levels. Reported studies have shown that exposure to the aryl hydrocarbon receptor (AHR) agonist, beta-naphthoflavone (BNF), resulted in decreased lactic acid levels in the mouse hepatocyte cell line, Hepa1.1. While previous studies in our lab were unable to confirm these findings, which may have been due to equipment limitations that required an up-scaling of the Lactic Acid Assay (LAA), exposure to apigenin and quercetin (two bioflavonoids and partial AHR agonists) in our hands were able to lower lactic acid levels in Hepa1.1 cells. In current studies we will use the preferred 96-well plate format with the LAA and examine the effects of BNF and bioflavonoid exposure in the human hepatocyte cell line, HepG2.

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