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STRUCTURAL ANALYSIS OF A BIOACTIVE GLASS CONTAINING NANOCERIA**

Abstract

Biodegradable glass is utilized as a creator and a carrier of mixed valence nanoceria. Studies have shown that the coexistence of Ce4+ and Ce3+ oxidation states on cerium oxide nanoparticles provides a number of health benefits, most notably the use of mixed valence nanoceria as antioxidant enzyme mimetics. The purpose of this study is to take the well-studied attributes of bioactive glass and merge it with the therapeutic potential of cerium oxide nanoparticles to create a stable glass that contains nanoceria with specific Ce3+/Ce4+ ratios and further releases these nanoparticles when the dissolved in aqueous media. In this study, a certain composition of glass is melted with varying (CeO2) and under different melting conditions to achieve different Ce3+/Ce4+ ratios. Through a solid-state reaction, Ce4+ and Ce3+ nanoparticles are created within the glass when melted at high temperature. The presence of mixed valence cerium oxide nanoparticles is confirmed by XRay Absorption Near Edge Structure (XANES) and Transmission Electron Microscopy (TEM). Furthermore, the novel bioactive glass containing specific ratios of Ce3+/Ce4+ is physiochemically characterized using SDT Q600 differential calorimetry and Fourier Transformed Infra-Red (FTIR) spectroscopy. The melting point, crystallization temperature, and the glass transition for these glasses was studied. These studies have shown that the melting temperature and glass transition temperatures remains fairly unchanged and the glass remains stable despite of various ratios of Ce4+ and Ce3+ nanoparticles. FT-IR analysis shows the effect of cerium oxide on bonds formed within the glass network.. The effect of the addition of CeO2 in glass melt, on Borate (BO3-3) and (BO4) oxidation was specifically observed. Increasing the concentration of the cerium oxide drove the formation of borate oxygen bonds B-O-B and possibly Ce-O-B bonds.

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