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Georgia Journal of Science

Article Title

DETERMINING THE ABILITY OF QUERCETIN AND RESVERATROL TO INHIBIT BAP-MEDIATED CYTOTOXICITY IN HEPG2 CELLS**

Abstract

Benzo[a]pyrene (BAP) is a commonly occurring carcinogen found in cigarette smoke and burnt meats. Previous studies have shown that resveratrol and quercetin are both able to inhibit AHR-mediated CYP1A1 expression by BAP, which is a required step in the bioactivation of BAP into its highly reactive diol epoxide metabolite, BPDE. It is not known, however, if these compounds are able to inhibit cytotoxicity. In these studies, human liver hepatocytes (HepG2) will be exposed to BAP to determined cell survivability via clonogenic assays. Cotreatment of BAP with either resveratrol or quercetin will also be examined to determine if these compounds can increase cell survivability.

Acknowledgements

GCSU Department of Biological and Environmental Sciences, Emily M. Friedman-Fechter, Garrett H. Medley, Jack C. McGarty

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