A TWELVE COMPONENT BIOACTIVE COMPOSITION FOR THE TREATMENT FOR Tb
The bacterium Mycobacterium tuberculosis, also referred to as MTb, infects individuals in latent, active and resistant forms. There are recommended regiments for the delivery of established antibiotics to infected individuals. These regiments focus on the oral administration and involve relatively large doses that result in significant side effects. This invention is a biodegradable implant composed primarily of an inert saturated fatty acid. The antibiotic is incorporated into the stearic acid matrix along with other constituents. The composition also includes a salt to regulate the release rate of the antibiotic, a metal-stearate structure to provide additional toxicity against MTb, a vitamin, and unsaturated fatty acids in low concentrations. As the fatty acid implant dissolves it forms a micelle that encapsulates the antibiotic. The micelle is transported to the infected area by serum and, since it is a primary energy source for the bacterium, is consumed. The antibiotic is hidden in the matrix. The biodegradable implant, which can be inserted as a single component or as spheres of different sizes (i.e. micrometer), does not have to be removed. It can also be inhaled. We have developed a relationship (signed agreement) with a company in India, which has 500 million citizens infected with Tb, to test the medical and business segments for commercialization. There is currently a patent application being prepared for the implant composition. This poster will focus on this project.
Johnson*, Courtney; Beard*, Torien; and Manning, Tom Dr.
"A TWELVE COMPONENT BIOACTIVE COMPOSITION FOR THE TREATMENT FOR Tb,"
Georgia Journal of Science, Vol. 78, No. 1, Article 104.
Available at: https://digitalcommons.gaacademy.org/gjs/vol78/iss1/104