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Georgia Journal of Science

Article Title

ANNOTATION OF THE lin-28 GENE ACROSS THREE SPECIES OF DROSOPHILA**

Abstract

The primary goal of the Pathways Project of the Genomics Education Partnership is to determine the evolution of the regulatory regions of the 64 genes in the insulin-signaling pathway across 28 Drosophila species. The insulin-signaling pathway is important because it regulates how sugars are processed and contributes to the growth and development of animals. This project will identify, annotate, and build gene models for the lin-28 gene in three species at various evolutionary distances from D. melanogaster: D. simulans, D. biarmipes, and D. willistoni. The lin-28 gene encodes a protein that regulates developmental timing and positively regulates the insulin-like receptor signaling pathway. These gene models and many others will allow the Pathways Project consortium to locate gene regulatory regions and compare them across the Drosophila genus. Additionally, we will assess the conservation among the three species of the genomic neighborhood, gene structure, and amino acid sequences of the gene products. Progress to date includes the complete annotation of the gene models of the D. biarmipes and D. willistoni species, while the D. simulans model still needs to be completed. Results indicate that the genomic neighborhood and overall gene structure are well conserved for both the D. biarmipes and D. willistoni species compared to D. melanogaster, and the amino acid sequence divergence corresponds to their phylogenetic distance from D. melanogaster.

Acknowledgements

Genomics Education Partnership, CSU Biology Department

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