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SYNTHESIS OF MESALAMINE AND CURCUMIN CAPPED SILVER NANOPARTICLES FOR THE TREATMENT OF IRRITABLE BOWEL DISEASE (IBD)**

Abstract

Silver nanoparticles are innovative materials which have found uses in the field of antiseptics and drug delivery systems as of late. The term IBD (Inflammatory Bowel Disease) is used to describe the series of chronic illnesses that are characterized by inflammation of the intestinal track lining. The two main diseases are Ulcerative Colitis (UC) and Crohns' disease (CD). One (UC) affects mainly the entirety of the colon while the other (CD) affects the entirety of the digestive system (from mouth to anus). To aid in the remission of an inflamed bowel, 5-ASAs (Mesalamine, balzalaside etc.) and curcumin are beneficial, alongside corticosteroids (prednisone) and biologics (Adalimumab and Infliximab). 5-ASAs (Mesalamine) are used to halt and avert flare-ups within the digestive tract while steroids and natural supplements such as curcumin, assist in the management of inflammatory and oxidative conditions. An effective synthesis of silver nanoparticles involves the use of silver nitrate, a capping agent (such as mercaptosuccinic acid) and a strong reducer (such as sodium borohydride). The two experiments were conducted while studying pH changes at each step. Then, UV-Vis was applied to verify the appearance of the nanoparticles. Signals around the 350-400 nm area confirmed the presence of silver nanoparticles in the two experiments. This work explores conditions that are used to synthesize these nanoparticles, that could be beneficial someday, in the delivery of therapeutic agents straight to intestinal lesions in the colon or digestive track.

Acknowledgements

GCSU Department of Chemistry, Physics and Astronomy

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