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Georgia Journal of Science

Article Title

SYNTHESIS AND BIOLOGICAL ACTIVITY OF N-SUBSTITUTED-BENZOTHIAZOLIUM SALTS UPON APPLICATION WITH ALS CELLS AND THE EFFECTS OF THE TDP-43 PROTEIN**

Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord. Motor neurons run from the brain to the muscles and impact voluntary muscle action where patients can lose the ability to speak, eat, move, and breathe. Riluzole is the only FDA-approved oral drug for ALS that has been shown to have little to no effects on the treatment and is a known benzothiazole compound. Using a series of substituted benzothiazoles that have been synthesized, this study will test these compounds on U2OS, SH-SY5Y, and HEK293T cells with overexpressed TDP-43 protein aggregates and their effects with each other. TDP-43 is a protein that is commonly found within the nervous system of sporadic ALS patients, that causes rapid pathogenic activities. During this process the cells will be analyzed for rate of growth in hopes of creating a cell model that will demonstrate an alternative therapeutic option for treating ALS. In this proposed project, I would like to use my organic chemistry skills to generate and identify new effective organic compounds to treat ALS.

Acknowledgements

Department of Chemistry, Columbus State University; Department of Biology, Columbus State University; Department of Chemistry, Texas Tech University; Department of Chemistry, Mercer University; Department of Chemistry, University of the District of Columbia

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